Lifelong bilingualism, cognitive reserve and Alzheimer’s disease

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A review of findings

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Abutalebi, J. , Canini, M. , Della Rosa, P.A. , Sheung, L.P. , Green, D.W. , & Weekes, B.S.
(2014) The neuroprotective effects of bilingualism upon the inferior parietal lobule: A Structural Neuroimaging Study in Aging Chinese Bilinguals. Journal of Neurolinguistics.
Albert, M.S. , Jones, K. , Savage, C.R. , Berkman, L. , Seeman, T. , Blazer, D. , & Rowe, J.W.
(1995) Predictors of cognitive change in older persons: MacArthur studies of successful aging. Psychol Aging, 10:578-589. doi: 10.1037/0882‑7974.10.4.578
Alladi, S. , Bak, T.H. , Duggirala, V. , Surampudi, B. , Shailaja, M. , Shukla, A.K. , Chaudhuri, J.R. , & Kaul, S.
(2013) Bilingualism delays age at onset of dementia, independent of education and immigration status. Neurology81:1938–1944. doi: 10.1212/01.wnl.0000436620.33155.a4
Amieva, H. , Jacqmin-Gadda, H. , Orgogozo, J.M. , Le Carret, N. , Helmer, C. , Letenneur, L. , Barberger-Gateau, P. , Fabrigoule, C. , & Dartigues, J.F.
(2005) The 9 year cognitive decline before dementia of the Alzheimer type: a prospective population-based study. Brain128:1093–1101. doi: 10.1093/brain/awh451
Bak, T.H. , Nissan, J.J. , Allerhand, M.M. , & Deary, I.J.
(2014) Does bilingualism influence cognitive aging? Ann Neurol75:959–963. doi: 10.1002/ana.24158
Bennett, D.A. , Schneider, J.A. , Tang, Y. , Arnold, S.E. , & Wilson, R.S.
(2006) The effect of social networks on the relation between Alzheimer's disease pathology and level of cognitive function in old people: a longitudinal cohort study. Lancet Neurol5:406–412. doi: 10.1016/S1474‑4422(06)70417‑3
Bialystok, E. , & Craik, F.I.M.
(2010) Cognitive and linguisitc processing in the bilingual mind. Current Directions in Psychological Science19:19–23. doi: 10.1177/0963721409358571
Bialystok, E. , Craik, F.I.M. , & Ryan, J.
(2006) Executive control in a modified antisaccade task: Effects of aging and bilingualism. J Exp Psychol Learn Mem Cogn32:1341–1354. doi: 10.1037/0278‑7393.32.6.1341
Bialystok, E. , Craik, F.I.M. , & Freedman, M.
(2007) Bilingualism as a protection against the onset of symptoms of dementia. Neuropsychologia45:459–464. doi: 10.1016/j.neuropsychologia.2006.10.009
Bialystok, E. , Craik, F.I.M. , & Luk, G.
(2012) Bilingualism: consequences for mind and brain. Trends Cogn Sci16:240–250. doi: 10.1016/j.tics.2012.03.001
Birks, J.
(2006) Cholinesterase inhibitors for Alzheimer's disease. Cochrane Database Syst Rev:CD005593. doi: 10.1002/14651858.CD005593
Bradl, M. , & Lassmann, H.
(2010) Oligodendrocytes: biology and pathology. Acta Neuropathol119:37–53. doi: 10.1007/s00401‑009‑0601‑5
Chertkow, H. , Whitehead, V. , Phillips, N. , Wolfson, C. , Atherton, J. , & Bergman, H.
(2010) Multilingualism (but not always bilingualism) delays the onset of Alzheimer disease: evidence from a bilingual community. Alzheimer Dis Assoc Disord24:118–125. doi: 10.1097/WAD.0b013e3181ca1221
Christensen, H.
(2001) What cognitive changes can be expected with normal ageing? The Australian and New Zealand journal of psychiatry35:768–775. doi: 10.1046/j.1440‑1614.2001.00966.x
Chua, T.C. , Wen, W. , Slavin, M.J. , & Sachdev, P.S.
(2008) Diffusion tensor imaging in mild cognitive impairment and Alzheimer's disease: a review. Curr Opin Neurol21:83–92. doi: 10.1097/WCO.0b013e3282f4594b
Convit, A. , De Leon, M.J. , Tarshish, C. , De Santi, S. , Tsui, W. , Rusinek, H. , & George, A.
(1997) Specific hippocampal volume reductions in individuals at risk for Alzheimer's disease. Neurobiol Aging18:131–138. doi: 10.1016/S0197‑4580(97)00001‑8
Costa, A. , Hernandez, M. , & Sebastian-Galles, N.
(2008) Bilingualism aids conflict resolution: evidence from the ANT task. Cognition106:59–86. doi: 10.1016/j.cognition.2006.12.013
Craik, F.I.M. , Bialystok, E. , & Freedman, M.
(2010) Delaying the onset of Alzheimer disease: bilingualism as a form of cognitive reserve. Neurology75:1726–1729. doi: 10.1212/WNL.0b013e3181fc2a1c
Craik, F.I.M. , & Salthouse, T.A.
Eds (2008) The Handbook of Aging and Cognition, Third Edition. New York, NY: Psychology Press.
Deary, I.J. , Gow, A.J. , Pattie, A. , & Starr, J.M.
(2012) Cohort profile: the Lothian Birth Cohorts of 1921 and 1936. International journal of epidemiology41:1576–1584. doi: 10.1093/ije/dyr197
Dickerson, B.C. , & Wolk, D.A.
(2012) MRI cortical thickness biomarker predicts AD-like CSF and cognitive decline in normal adults. Neurology78:84–90. doi: 10.1212/WNL.0b013e31823efc6c
Dickerson, B.C. , Bakkour, A. , Salat, D.H. , Feczko, E. , Pacheco, J. , Greve, D.N. , Grodstein, F. , Wright, C.I. , Blacker, D. , Rosas, H.D. , Sperling, R.A. , Atri, A. , Growdon, J.H. , Hyman, B.T. , Morris, J.C. , Fischl, B. , & Buckner, R.L.
(2009) The cortical signature of Alzheimer's disease: regionally specific cortical thinning relates to symptom severity in very mild to mild AD dementia and is detectable in asymptomatic amyloid-positive individuals. Cereb Cortex19:497–510. doi: 10.1093/cercor/bhn113
Farrimond, L.E. , Roberts, E. , & McShane, R.
(2012) Memantine and cholinesterase inhibitor combination therapy for Alzheimer's disease: a systematic review. BMJ open2. doi: 10.1136/bmjopen‑2012‑000917
Fernandes, M.A. , Craik, F.I.M. , Bialystok, E. , & Kreuger, S.
(2007) Effects of bilingualism, aging, and semantic relatedness on memory under divided attention. Can J Exp Psychol61:128–141. doi: 10.1037/cjep2007014
Gold, B.T. , Johnson, N.F. , Powell, D.K. , & Smith, C.D.
(2012) White matter integrity and vulnerability to Alzheimer's disease: preliminary findings and future directions. Biochim Biophys Acta1822:416–422. doi: 10.1016/j.bbadis.2011.07.009
Gold, B.T. , Johnson, N.F. , & Powell, D.K.
(2013a) Lifelong bilingualism contributes to cognitive reserve against white matter integrity declines in aging. Neuropsychologia51:2841–2846. doi: 10.1016/j.neuropsychologia.2013.09.037
Gold, B.T. , Kim, C. , Johnson, N.F. , Kryscio, R.J. , & Smith, C.D.
(2013b) Lifelong bilingualism maintains neural efficiency for cognitive control in aging. J Neurosci33:387–396. doi: 10.1523/JNEUROSCI.3837‑12.2013
Gold, B.T.
(2015) Lifelong Bilingualism and Neural Reserve against Alzheimer's disease: A Review of Findings and Potential Mechanisms. Behavioural Brain Research281C, 9–15. doi: 10.1016/j.bbr.2014.12.006
Good, C.D. , Johnsrude, I.S. , Ashburner, J. , Henson, R.N. , Friston, K.J. , & Frackowiak, R.S.
(2001) A voxel-based morphometric study of ageing in 465 normal adult human brains. Neuroimage14:21–36. doi: 10.1006/nimg.2001.0786
Grady, C.L. , Luk, G. , Craik, F.I.M. , & Bialystok, E.
(2015) Brain network activity in monolingual and bilingual older adults. Neuropsychologia66:170–181. doi: 10.1016/j.neuropsychologia.2014.10.042
Green, D.W.
(1998) Mental control of the bilingual lexico-semantic system. Bilingualism: Language and Cognition1:67–81. doi: 10.1017/S1366728998000133
Green, D.W. , & Abutalebi, J.
(2013) Language control in bilinguals: The adaptive control hypothesis. J Cogn Psychol (Hove) 25:515–530. doi: 10.1080/20445911.2013.796377
Gyllensten, L. , & Malmfors, T.
(1963) Myelinization of the optic nerve and its dependence on visual function--a quantitative investigation in mice. J Embryol Exp Morphol11:255–266.
Hillman, C.H. , Erickson, K.I. , & Kramer, A.F.
(2008) Be smart, exercise your heart: exercise effects on brain and cognition. Nat Rev Neurosci9:58–65. doi: 10.1038/nrn2298
Jack, C.R., Jr. , Petersen, R.C. , Xu, Y.C. , Waring, S.C. , O'Brien, P.C. , Tangalos, E.G. , Smith, G.E. , Ivnik, R.J. , & Kokmen, E.
(1997) Medial temporal atrophy on MRI in normal aging and very mild Alzheimer's disease. Neurology49:786–794. doi: 10.1212/WNL.49.3.786
Josefsson, K. , Jokela, M. , Cloninger, C.R. , Hintsanen, M. , Salo, J. , Hintsa, T. , Pulkki-Raback, L. , & Keltikangas-Jarvinen, L.
(2013) Maturity and change in personality: developmental trends of temperament and character in adulthood. Dev Psychopathol25:713–727. doi: 10.1017/S0954579413000126
Kemper, T.L.
(1994) Neuroanatomical and neuropathological changes during aging and in dementia. In: Clinical Neurology of Aging ( Albert, M.L. , & Knoepfel, E.J.E. , eds), pp3–67. New York: Oxford University Press.
Kim, C. , Cilles, S.E. , Johnson, N.F. , & Gold, B.T.
(2012) Domain general and domain preferential brain regions associated with different types of task switching: a meta-analysis. Hum Brain Mapp33:130–142. doi: 10.1002/hbm.21199
Luk, G. , Bialystok, E. , Craik, F.I.M. , & Grady, C.L.
(2011) Lifelong bilingualism maintains white matter integrity in older adults. J Neurosci31:16808–16813. doi: 10.1523/JNEUROSCI.4563‑11.2011
Madden, D.J. , Bennett, I.J. , Burzynska, A. , Potter, G.G. , Chen, N.K. , & Song, A.W.
(2012) Diffusion tensor imaging of cerebral white matter integrity in cognitive aging. Biochim Biophys Acta1822:386–400. doi: 10.1016/j.bbadis.2011.08.003
Martensson, J. , Eriksson, J. , Bodammer, N.C. , Lindgren, M. , Johansson, M. , Nyberg, L. , & Lovden, M.
(2012) Growth of language-related brain areas after foreign language learning. Neuroimage63:240–244. doi: 10.1016/j.neuroimage.2012.06.043
Martin, S.B. , Smith, C.D. , Collins, H.R. , Schmitt, F.A. , & Gold, B.T.
(2010) Evidence that volume of anterior medial temporal lobe is reduced in seniors destined for mild cognitive impairment. Neurobiol Aging31:1099–1106. doi: 10.1016/j.neurobiolaging.2008.08.010
Mayeux, R.
(2003) Epidemiology of neurodegeneration. Annu Rev Neurosci26:81–104. doi: 10.1146/annurev.neuro.26.043002.094919
McKhann, G. , Drachman, D. , Folstein, M. , Katzman, R. , Price, D. , & Stadlan, E.M.
(1984) Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology34:939–944. doi: 10.1212/WNL.34.7.939
Miller, E.K. , & Cohen, J.D.
(2001) An integrative theory of prefrontal cortex function. Annu Rev Neurosci24:167–202. doi: 10.1146/annurev.neuro.24.1.167
Mortimer, J.A.
(1997) Brain reserve and the clinical expression of Alzheimer's disease. Geriatrics 52 Suppl2:S50–53.
Petrosini, L. , De Bartolo, P. , Foti, F. , Gelfo, F. , Cutuli, D. , Leggio, M.G. , & Mandolesi, L.
(2009) On whether the environmental enrichment may provide cognitive and brain reserves. Brain research reviews61:221–239. doi: 10.1016/j.brainresrev.2009.07.002
Raz, N. , & Kennedy, K.M.
(2009) A systems approach to age-related change: Neuroanatomical changes, their modifiers, and cognitive correlates. In: Imaging the Aging Brain ( Jagust, W. , & Desposito, M. , eds), pp43–70. New York, NY: Oxford University Press. doi: 10.1093/acprof:oso/9780195328875.003.0004
Raz, N. , Lindenberger, U. , Rodrigue, K.M. , Kennedy, K.M. , Head, D. , Williamson, A. , Dahle, C. , Gerstorf, D. , & Acker, J.D.
(2005) Regional brain changes in aging healthy adults: general trends, individual differences and modifiers. Cereb Cortex15:1676–1689. doi: 10.1093/cercor/bhi044
Resnick, S.M. , Pham, D.L. , Kraut, M.A. , Zonderman, A.B. , & Davatzikos, C.
(2003) Longitudinal magnetic resonance imaging studies of older adults: a shrinking brain. J Neurosci23:3295–3301.
Richards, M. , & Deary, I.J.
(2005) A life course approach to cognitive reserve: a model for cognitive aging and development? Ann Neurol58:617–622. doi: 10.1002/ana.20637
Riley, K.P. , Snowdon, D.A. , & Markesbery, W.R.
(2002) Alzheimer's neurofibrillary pathology and the spectrum of cognitive function: findings from the Nun Study. Ann Neurol51:567–577. doi: 10.1002/ana.10161
Robbins, T.W. , & Arnsten, A.F.
(2009) The neuropsychopharmacology of fronto-executive function: monoaminergic modulation. Annu Rev Neurosci32:267–287. doi: 10.1146/annurev.neuro.051508.135535
Salthouse, T.A.
(1996) The processing-speed theory of adult age differences in cognition. Psychol Rev103:403–428. doi: 10.1037/0033‑295X.103.3.403
Schaie, K.W.
(1996) Intellectual Development in Adulthood: The Seattle Longitudinal Study. Cambridge: Cambridge University Press.
Schmidtke, K. , & Hull, M.
(2005) Cerebral small vessel disease: how does it progress? J Neurol Sci229–230:13–20.
Schweizer, T.A. , Ware, J. , Fischer, C.E. , Craik, F.I.M. , & Bialystok, E.
(2012) Bilingualism as a contributor to cognitive reserve: evidence from brain atrophy in Alzheimer's disease. Cortex48:991–996. doi: 10.1016/j.cortex.2011.04.009
Shaw, L.M. , Vanderstichele, H. , Knapik-Czajka, M. , Clark, C.M. , Aisen, P.S. , Petersen, R.C. , Blennow, K. , Soares, H. , Simon, A. , Lewczuk, P. , Dean, R. , Siemers, E. , Potter, W. , Lee, V.M. , & Trojanowski, J.Q.
(2009) Cerebrospinal fluid biomarker signature in Alzheimer's disease neuroimaging initiative subjects. Ann Neurol65:403–413. doi: 10.1002/ana.21610
Smith, C.D. , Chebrolu, H. , Wekstein, D.R. , Schmitt, F.A. , & Markesbery, W.R.
(2007) Age and gender effects on human brain anatomy: a voxel-based morphometric study in healthy elderly. Neurobiol Aging28:1075–1087. doi: 10.1016/j.neurobiolaging.2006.05.018
Smith, C.N. , & Squire, L.R.
(2009) Medial temporal lobe activity during retrieval of semantic memory is related to the age of the memory. J Neurosci29:930–938. doi: 10.1523/JNEUROSCI.4545‑08.2009
Spires, T.L. , & Hannan, A.J.
(2005) Nature, nurture and neurology: gene-environment interactions in neurodegenerative disease. FEBS Anniversary Prize Lecture delivered on 27 June 2004 at the 29th FEBS Congress in Warsaw. FEBS J272:2347–2361.
Spreng, R.N. , Sepulcre, J. , Turner, G.R. , Stevens, W.D. , & Schacter, D.L.
(2013) Intrinsic architecture underlying the relations among the default, dorsal attention, and frontoparietal control networks of the human brain. J Cogn Neurosci25:74–86. doi: 10.1162/jocn_a_00281
Squire, L.R.
(1992) Memory and the hippocampus: a synthesis from findings with rats, monkeys, and humans. Psychol Rev99:195–231. doi: 10.1037/0033‑295X.99.2.195
Stebbins, G.T. , & Murphy, C.M.
(2009) Diffusion tensor imaging in Alzheimer's disease and mild cognitive impairment. Behav Neurol21:39–49. doi: 10.1155/2009/915041
Steffener, J. , & Stern, Y.
(2012) Exploring the neural basis of cognitive reserve in aging. Biochim Biophys Acta1822:467–473. doi: 10.1016/j.bbadis.2011.09.012
Stein, M. , Federspiel, A. , Koenig, T. , Wirth, M. , Strik, W. , Wiest, R. , Brandeis, D. , & Dierks, T.
(2012) Structural plasticity in the language system related to increased second language proficiency. Cortex48:458–465. doi: 10.1016/j.cortex.2010.10.007
Stern, Y. , Alexander, G.E. , Prohovnik, I. , & Mayeux, R.
(1992) Inverse relationship between education and parietotemporal perfusion deficit in Alzheimer's disease. Ann Neurol. 32:371–5. doi: 10.1002/ana.410320311
Stern, Y.
(2002) What is cognitive reserve? Theory and research application of the reserve concept. J Int Neuropsychol Soc8:448–460. doi: 10.1017/S1355617702813248
(2009) Cognitive reserve. Neuropsychologia47:2015–2028. doi: 10.1016/j.neuropsychologia.2009.03.004
Tisserand, D.J. , van Boxtel, M.P. , Pruessner, J.C. , Hofman, P. , Evans, A.C. , & Jolles, J.
(2004) A voxel-based morphometric study to determine individual differences in gray matter density associated with age and cognitive change over time. Cereb Cortex14:966–973. doi: 10.1093/cercor/bhh057
Valenzuela, M.J. , & Sachdev, P.
(2006) Brain reserve and dementia: a systematic review. Psychol Med36:441–454. doi: 10.1017/S0033291705006264
Van Dijk, K.R.A. , Van Gerven, P.W.M. , Van Boxtel, M.P.J. , Van der Elst, W. , & Jolles, J.
(2008) No Protective Effects of Education During Normal Cognitive Aging: Results From the 6-Year Follow-Up of the Maastricht Aging Study. Psychology and Aging23:119–130. doi: 10.1037/0882‑7974.23.1.119
Vlassenko, A.G. , Benzinger, T.L. , & Morris, J.C.
(2012) PET amyloid-beta imaging in preclinical Alzheimer's disease. Biochim Biophys Acta1822:370–379. doi: 10.1016/j.bbadis.2011.11.005
Yeung, C.M. , St John, P.D. , Menec, V. , & Tyas, S.L.
(2014) Is Bilingualism Associated With a Lower Risk of Dementia in Community-living Older Adults? Cross-sectional and Prospective Analyses. Alzheimer Dis Assoc Disord. doi: 10.1097/WAD.0000000000000019
Zahodne, L.B. , Schofield, P.W. , Farrell, M.T. , Stern, Y. , & Manly, J.J.
(2014) Bilingualism does not alter cognitive decline or dementia risk among Spanish-speaking immigrants. Neuropsychology28:238–246. doi: 10.1037/neu0000014
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